Glycomate

Reversing Diabetes

Remission (or reversal) is possible most likely in the early stage of diabetes or after a big weight loss. It can also happen after bariatric surgery for weight loss, which can trigger recovery of the beta cells.


What does curing diabetes really mean for you?

Think curing diabetes is easy? The internet is full of promises and no one has closed the sites, so they must be true. Right?

What do we know for sure? There is no known cure for type 2 diabetes. But it can be well controlled. And in some cases, it goes into remission. The digital world is full of promises which are “too good to be true” and are unproven.

Internet sites have appeared selling diabetes “cures”. These sites use jargon and language which preys on people who struggle to live with the burden of their diabetes and want to be rid of it. They want the cure because they keep getting told that they have a chronic, progressive disease.

These quick fix cures are usually sold under a brand name, and touted as being ‘100% effective in curing diabetes’. Others share their own personal success stories or the success story of someone they know and offer to share the secret for free – that is, until you have to buy some mixture they found in a far-off country.

These “cures” are sold as being a natural blend of a variety of herbs that lower and control blood glucose levels without the need for diabetes medication or insulin. They then go further to promise that you can stop taking your medications.

What does curing diabetes really mean for you? Curing diabetes is not like curing cancer where the cancer is removed and there is no further sign of the cancer ever having been there. The cancer is eliminated.


To eliminate diabetes, we need to understand what causes type 2 diabetes. Insulin resistance, failure of the pancreas, and a genetic susceptibility are all connected in the development of diabetes. This has led to the belief that type 2 diabetes is unavoidably progressive (1).


It is now understood that type 2 diabetes has the potential to be a “reversible” metabolic condition, triggered by the single cause of chronic fatty deposits into organs, especially the liver and pancreas.


Simply put, the fatty deposits in the liver lead to insulin resistance. In turn the pancreas responds with extra insulin release, to overcome the resistance to keep the blood glucose level normal. This excess insulin forces more fat into the liver, making the insulin resistance worse. The pancreas must work even harder. This causes the insulin producing cells of the pancreas to become exhausted and unable to meet the body’s demand for more insulin. The body’s blood glucose levels trend up, revealing the diabetes.


We don’t do expensive tests for insulin resistance but we use a proxy marker. A waist measurement more than 98 cm in males and 88 cm in females tells us that these people are overweight or obese and will have some degree of insulin resistance.


Being overweight or obese does not mean you will definitely develop diabetes. If it did then more than 60% of people in our society would have type 2 diabetes. This is not the case. If you carry too much fat around the belly you are more at risk, but you must have the genetic susceptibility to develop diabetes.


To eliminate diabetes, we must address insulin resistance and pancreatic failure. We cannot change a genetic identity.


Almost 25 years ago, bariatric surgery showed that type 2 diabetes can be fully reversed. The surgeons say “cured” and the physicians say “reversed”.

Fact 1: To eliminate diabetes, you need to reduce fatty infiltrate in the liver. This can be done surgically, through the bariatric weight loss processes, or through reduced calorie diets that are sustainable long term.

Chronic exposure of the insulin producing cells of the pancreas to fat reduces the ability of the cells to release insulin in response to an increase in blood glucose (3).

Fact 2: To eliminate diabetes you need to reduce pancreas failure. This can be done by reducing fat toxicity through weight loss.

Studies have shown that one person can have normal pancreas function with 8% fat in their pancreas while another develops diabetes with 5% fat in their pancreas. This susceptibility to fat toxicity is the genetic element (2).


Fact 3: If the fat is simply not available to the body then the susceptibility of the pancreas will not be tested. If the person has acquired excess fat stores through their diet intake, pancreas failure may or may not develop depending on the degree of susceptibility.

The cure for diabetes is not a tablet. It is not a herbal drink. It is not a series of vitamin supplements. The cure or elimination of type 2 diabetes rests solely with reducing fatty infiltration of the body’s organs, especially the liver and keeping the organ free of and protected from fat toxicity. No tablets, herbal preparation or mixtures will cure type 2 diabetes.

There is no cure for diabetes. It can be eliminated, but because of the genetic predisposition it cannot be called a cure. It must be called remission.


What is remission (or reversal)?

  • "Complete remission" is 1 year or more of normal A1c and fasting glucose levels without using diabetes medicine.

  • "Prolonged remission" is 5 years or more of normal A1c and blood sugar levels without using diabetes medicine.


Remission is possible most likely in the early stage of diabetes or after a big weight loss. It can also happen after bariatric surgery for weight loss, which can trigger recovery of the beta cells.

Remission is less likely but not impossible in the later stages of diabetes, because the beta cells may regress.


The goal for any person living with diabetes must be to achieve remission and maintain this with lifestyle changes after significant weight loss (4). Where this is not possible well controlled diabetes will afford the same benefits as with remission - but with medications achieving the outcomes. Quick fix cures will fail as quickly as they promise a fix.



References

  1. Turner RC, Cull CA, Frighi V, Holman RR, UK Prospective Diabetes Study (UKPDS) Group. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA 1999;281:2005–2012pmid:10359389.

  2. Szczepaniak LS, Victor RG, Mathur R, et al. Pancreatic steatosis and its relationship to β-cell dysfunction in humans: racial and ethnic variations. Diabetes Care 2012;35:2377–2383pmid:22968187.

  3. Tushuizen ME, Bunck MC, Pouwels PJ, et al. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007;30:2916–2921pmid:17666465.

  4. Wing RR, Phelan S. Long-term weight loss maintenance. Am J Clin Nutr 2005;82(Suppl.):222S–225Spmid:16002825.


Want To Achieve Remission?

Glycomate will help you set goals to achieve remission and maintain with lifestyle changes.